Nano Hydroxyapatite vs Hydroxyapatite | Benefits Explained

Nano-hydroxyapatite is a synthetic, crystalline material often used in dental and orthopedic applications. It's also an alternative source of calcium in treating osteoporosis, decreasing the rate at which bone tissue breaks down. This article will provide information about the composition and properties of nano-hydroxyapatite vs hydroxyapatite, the parent compound.


    Key Takeaways

  • Nano-hydroxyapatite has a higher bioactivity than traditional hydroxyapatite.
  • Nano-hydroxyapatite toothpaste can be loaded with different materials to enhance its properties for other applications.
  • Nano-hydroxyapatite has a unique crystal structure that is not found in natural sources, making it ideal for bone regeneration. 
  • Hydroxyapatite is a common ingredient in toothpaste to help reconstruct periodontal bone defects.


Hydroxyapatite is the main mineral in bones, so it's no surprise that researchers have been studying ways to use it in dentistry and orthopedics. One of these methods is nano-hydroxyapatite, which has superior properties to traditional HA when applied topically or implanted into tissue.

A tooth made of toothpaste

Nano-Hydroxyapatite vs Hydroxyapatite

Nano-hydroxyapatite and regular hydroxyapatite are differentiated by the molecular size of the product and its ability to penetrate the skin. When it comes to penetration, nano-hydroxyapatite has a higher percentage of calcium than regular hydroxyapatite. It means that it penetrates deeper into your skin when applied topically. Nano also contains smaller molecules, making them easier to absorb into your body.

The main difference between these two products is their size. Nano-sized particles are smaller than regular-sized particles. The larger particle sizes can apply more pressure on various areas of your face or body. However, this can lead to irritation and discomfort if you have sensitive skin and should get avoided if possible!


Nano-Hydroxyapatite is a biocompatible material used in the treatment of osteoporosis by dental professionals. Nano-Hydroxyapatite is FDA approved and is safe when following manufacturer directions. It is composed of calcium, phosphate, and oxygen, all-natural substances in the human body. These minerals help build stronger bones by enhancing the body's ability to absorb them from other sources like food or supplements when taken orally (swallowed).

In several studies, Nano-hydroxyapatite toothpaste, which replaced fluoride toothpaste, works effectively to reverse bone loss caused by osteoporosis. However, it has yet to get approval for use as an alternative treatment for bone loss and for preventing dental caries. The main reason for this is its high cost compared with other medications available today.

Putting paste on a toothbrush

Get 15% Off with discount code (use at checkout): BLOG15

Hydroxyapatite (micro-sized)

Hydroxyapatite is a naturally occurring mineral found in your bones and teeth. It's also used as a dental filling material because it can help strengthen tooth enamel surfaces by creating a protective layer over the damaged area. It also helps reverse tooth decay.

Hydroxyapatite powder is also used for bone grafts and bone scaffolds (structures that guide new tissue growth).

  • Therapeutic targets of nano-hydroxyapatite and hydroxyapatite.
  • Nano-hydroxyapatite is used to treatosteoporosis, periodontal disease, and rheumatoid arthritis.
  • Hydroxyapatite is also used as a supplement to strengthen your bones and teeth.
  • Biological responses on the nanoparticles.
  • The nanoparticles are biocompatible, which means you can use them without causing any harm.
  • The nanoparticles are also biodegradable, dissolving into smaller units over time and eventually disappearing from the body.
  • The nanoparticles are not toxic for humans at all levels of exposure. So you don't have to worry about adverse side effects when using them!
  • Finally, in vivo tests have shown that hydroxyapatite is stable and non-cytotoxic (cell-killing).

Summary of the Differences Between Nano-Hydroxyapatite and Hydroxyapatite

Nano-hydroxyapatite is a synthetic form of hydroxyapatite modified with a nano-scale crystalline structure. It gets produced by synthesizing hydroxyapatite in solution followed by rapid cooling to solidify it into its nano-scale system. Hydroxyapatite is naturally found in bone tissue, and dentists have used it as a bone graft material since the 1960s. However, the material got modified to be more efficient at healing bone defects and biocompatible with human cells.

The main difference between these two materials is their surface area. Nano-hydroxyapatite has a much larger surface area than hydroxyapatite, composed of many tiny crystalsinstead of just one large crystal. As a result, it results in better absorption of nutrients and improved tissue adhesion between the graft material and surrounding tissues (e.g., bone).

A smile and toothpaste on a brush

Which Is Better, Nano-Hydroxyapatite or Fluoride?

Proponents of nano hydroxyapatite state it’s a safe replacement for fluoride, however it works much in the same way. Hydroxylapatite is a calcium phosphate salt that looks like a white powder, unlike fluoride. It has been used in regenerative dentistry since the 1970s to repair small cavities and cracks in teeth. Fluoride is a mineral that occurs naturally in many foods and drinking water. It's also added to some toothpaste and other oral care products to help prevent tooth decay.

Amine fluoride toothpaste makes the tooth enamel more resistant to decay by helping remineralize weakened areas of enamel that causesdental fluorosis. In addition, hydroxyapatite helps repair minor cracks andfissures in enamel caused by acids produced during eating or drinking acidic foods and beverages.

Both hydroxyapatite and fluoride toothpastes essentially work differently:

  • Hydroxyapatite toothpaste helps repair cavities when they're still small — before they become large enough to cause pain or damage to your teeth or gums
  • Fluoride toothpaste helps prevent cavities from forming by strengthening your tooth enamel, making it less likely to decay over time

Which Toothpaste Has the Highest Amount of Hydroxyapatite?

The hydroxyapatitetoothpaste for sensitive teeth contains the most hydroxyapatite. It's a mineral present in the teeth naturally, but brushing the teeth and other activities can deplete it.

Your teeth's dentin layer is visible when the enamel wears away. It causes teeth sensitivity to cold or hot foods and beverages. 

The enamel wears away because of a lack of minerals such as calcium, phosphate, fluoride, and fluoride. These minerals are found in a good hydroxyapatite toothpaste containing calcium carbonate or calcium and phosphate.

Hydroxyapatite toothpaste is referred to as remineralizing toothpasteIt's because hydroxyapatite helps restore minerals like calcium and phosphate into your teeth where they belong!

Question marks made out of toothpaste


1. Does Nano-Hydroxyapatite Remineralize Teeth?

Yes, with Nano-hydroxyapatite toothpastes, your teeth will remineralize more quickly and effectively than other products. And because of its smaller size, it can penetrate deep into the crevices between your teeth and the roots, strengthening the enamel surface.

2. Can Nano-Hydroxyapatite Reverse Cavities?

Yes. Nano-hydroxyapatite helps to reverse early dental decay, even in patients who have not received fluoride treatment for up to 12 months. In addition, as the nanoparticles can penetrate thedentinal tubules, they will reach areas other products cannot reach and help prevent future decay.

3. Do I Need a Prescription to Order Nano-hydroxyapatite?

You do not need a prescription to order Nano-hydroxyapatite. You can purchase and start using it without any medication. However, if you have doubts about the product, consult your doctor.

4. Is Nano-hydroxyapatite Safe?

Yes! Nano-hydroxyapatite is a naturally occurring mineral used for decades in dental applications. It is FDA approved and is safe when used appropriately according to manufacturer directions.

5. Does Hydroxyapatite Promote Enamel Regrowth?

Yes, hydroxyapatite does not regrow enamel. It is not living tissue. Therefore, remineralization with hydroxyapatite will not undo the damage. Instead, remineralization only serves to fortify the enamel.

The two compounds are very similar in their chemical composition and properties. For example, they both have hydroxyl groups, which can bind with other substances, making them complex. However, nano-hydroxyapatite is smaller than its regular counterpart, which makes it more effective in many applications, includingbioactive materials.