Is Nano-Hydroxyapatite Safe? | We Addressed Your Concerns!

Nano-hydroxyapatite (Nano-HA) is a relatively new compound attracting attention due to its potential health benefits. But with any new product or technology, it’s important to seek clarity over the safety of oral care products


      Key Takeaways

  • Nano-HA is a unique substance that has proven effective in treating tooth sensitivity.
  • Every time you brush your teeth, Nano-HA penetrates your tooth enamel and replenishes the minerals that have been lost, providing the best alternative to fluoride.
  • Despite being utilized for years in many countries, Nano-HA is still awaiting FDA approval in the United States.
  • Using nanotechnology, scientists have developed a method for converting hydroxyapatite into nano-sized particles that act towards remineralizing your teeth.



Is Nano-Hydroxyapatite safe? This element boasts hydroxyapatite nanoparticles which create a powerful barrier around each tooth to keep out bacteria, helping prevent cavities and decay from forming within your teeth. Let’s explore some of the safety concerns associated with Nano-HA and provide an overall evaluation of its safety. Despite this, at Dr. Brite, we have safe and effective kinds of toothpaste that are plant-based and free from any toxins.

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Is Nano-Hydroxyapatite Safe?

Hydroxyapatite (HA) is a natural mineral that’s been around for thousands of years. Using modern technology, scientists convert HA into nanoparticles, known as Nano-HA. This substance is a crucial ingredient in toothpaste, mouthwash, and other oral care products. However, it is not safe for use owing to the many unanswered questions. To be on the safe side, only use government-approved products. In this case,  Dr. Brite Toothpaste provides the best solution to all oral health issues. 

Nano-Hydroxyapatite Euro ban

The European Union (EU) banned using nano-hydroxyapatite in cosmetics years ago. The EU was concerned that the skin could absorb the tiny particles and accumulate in organs, with unknown consequences.

Several years later, there is still no scientific consensus on the safety of nano-hydroxyapatite. Some studies have found that it can cause inflammation and damage DNA, while others have found no adverse effects.

The lack of definitive data has led to a continued debate among scientists, regulators, and industry representatives. In 2016, the EU’s Scientific Committee on Consumer Safety (SCCS) issued a new opinion on nano-hydroxyapatite, concluding that there is still insufficient data to assess its safety.

The SCCS opinion is non-binding, but it will likely influence the EU’s decision to lift or maintain the ban on nano-hydroxyapatite.

Toothpaste on a toothbrush

Is Nano-hydroxyapatite FDA Approved?

Although People have used Nano-HA for many years in countries like Japan, Netherlands, and Canada, the FDA has yet to approve it in the US. It’s essential to understand the benefits as well as drawdowns of this additive, given that various studies suggest that it may be a perfect substitute for fluoride.

Can Nano-HA Reverse Cavities?

It’s a no-brainer that this product can’t reverse cavities. But if you want to keep your teeth healthy, Nano-HA might be the next best thing. 

Nano-HA is an extract that acts as a protective shield on the surface of your teeth. When placed on a tooth and left for at least 30 minutes, it forms a protective coating around each layer of enamel, preventing bacteria; this means fewer cavities and better overall health.


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Is Nano-HA Natural?

Nano-HA is the synthetic version of hydroxyapatite. Its history spans four decades and is rather interesting. In 1970, NASA developed the first version of Nano-HA.

Due to prolonged stays in a zero-gravity environment, astronauts returning from space missions were experiencing mineral loss from their teeth and bones. To replace what was lost, experts developed Nano-HA.

Nano-HA comprises calcium elements processed into tiny particles through high heat and pressure to make them more stable.

Does Nano-HA Rebuild Teeth?

When you use Nano-HA toothpaste to brush your teeth, it restores the minerals you have lost by combining them with the existing hydroxyapatite. This act enhances the microhardness of the eroded tooth.

In regions where acids have dissolved calcium and phosphates, Nano-HA immediately restores their amounts by penetrating the enamel’s surface.

Benefits of Nano-HA

Over the years, experts have demonstrated that Nano-HA has numerous health benefits. Here are some of them.

  • Every time you brush your teeth, nanoparticles in this substance penetrate your enamel and replenish your lost minerals.
  • It gradually repairs your tooth surface with natural minerals resulting in polished and whitened teeth.
  • To significantly lessen tooth sensitivity, it plugs exposed dentin tubules.
  • It prevents tooth decay by offering complete defense against damaging food acids.
  • It is non-toxic, bioactive, and osteoconductive. 
  • It stimulates bone growth and corrects dentin hypersensitivity.

Green toothpaste

How Does Nano-hydroxyapatite Toothpaste Compare to Fluoride Toothpaste?

It’s no secret that Nano-HA and fluoride protect against tooth decay while bolstering enamel. However, the two have some differences. Here are the major ones.

  1. Fluoride toxicity can result from excessive fluoride exposure and has unpleasant side effects. That’s why amine fluoride toothpaste has a poison control label. In contrast, there is no concern about overexposure or requirement for a poison control label with nano-hydroxyapatite toothpaste because the element is nontoxic and biomimetic.
  2. Hydroxyapatite toothpaste is better for your oral and gut microbiomes because it is biocompatible, which means it already exists in your body in the form of HA and interacts with its natural systems and materials. Additionally, unlike fluoride, Nano-HA doesn’t instantly eradicate the beneficial, necessary microorganisms in your gut and mouth microbiomes.
  3. Unlike fluoride, hydroxyapatite toothpaste can whiten your teeth without additional whitening agents. To do this, it penetrates the enamel, fixes flaws, and replenishes the required minerals to give you a radiant smile.

How Long Does Nano-HA Toothpaste Help With Tooth Sensitivity?

You should start by using the toothpaste for 1-4 weeks. Regular use of Nano-HA toothpaste can help tooth sensitivity for months since many types of bacteria live on our teeth and gums, which cause inflammation and pain when they come in contact with our teeth or gums. The nano-hydroxyapatite particles break down these bacteria, so they cannot cause any harm.

Cartooned toothpastes

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How Does Nano-HA Feel on Your Teeth?

You may have been concerned that Nano-HA would feel gritty or grainy, but it doesn’t. You’ll be pleasantly surprised at how awesome the treatment feels when you rinse it off with water after brushing your teeth. Using nano-hydroxyapatite toothpaste has a marble-like feeling similar in texture to regular toothpaste, so if you’re used to brushing with abrasives, this new type of cleaning will feel different. And because it’s so gentle on your teeth and gums, there’s no need for a second round of rinsing after using hydroxyapatite toothpaste. Just let the foam sit on top of them for about 30 seconds before brushing again with your regular cleaning routine!


1. Did the EU ban Nano-HA? 

Yes, Nano-HA is still facing a Euro ban. The ban was based on concerns that the tiny particles could be absorbed through the skin and accumulate in organs. 

2. Is Nano-HA FDA Approved?

No, Nano-HA is not FDA Approved. However, it has been used in countries like Japan, Netherlands, and Canada for many years. Various studies suggest that it may be a perfect substitute for fluoride.

3. Is Nano-HA Natural?

No. Nano-HA is not natural. However, it is derived from hydroxyapatite, a naturally occurring mineral with benefits such as protecting teeth from decay.

4. How Does Nano-HA Feel on Your Teeth?

Nano-HA leaves you with a soft and smooth feeling. It is not any different from regular toothpaste. If anything, it leaves a pleasant taste in the mouth.